Bounding the per-protocol effect in randomized trials: an application to colorectal cancer screening
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Bounding the per-protocol effect in randomized trials: an application to colorectal cancer screening
BACKGROUND The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effect may be estimated under more plausible assumptions. Strategies for obtainin...
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ژورنال
عنوان ژورنال: Trials
سال: 2015
ISSN: 1745-6215
DOI: 10.1186/s13063-015-1056-8